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Objective:To investigate the efficacy of MR radiomics in predicting the transformation of amnesic mild cognitive impairment (aMCI) into Alzheimer′s disease (AD).Methods:The clinical and imaging data of 30 patients with aMCI diagnosed in the First Hospital of Shanxi Medical University from December 2018 to December 2020 and 190 aMCI cases from public databases were retrospectively analyzed. The study population included 120 males and 110 females, aging from 50 to 80 years old. Thirty-nine cases progressed to AD, and 181 cases did not progress to AD. They were randomly divided into a training set (154 cases) and a validation set (66 cases) with a ratio of 7∶3. The edges of the bilateral hippocampus were manually delineated layer by layer on the transverse, coronal, sagittal images of T 1WI three-dimensional magnetization preparatory gradient echo sequence to obtain a three-dimensional labeled image, and then the radiomics features of the left hippocampus, right hippocampus, and combined bilateral hippocampus were extracted and screened, respectively. Finally, a radiomics label was constructed. Receiver operating characteristic (ROC) curves were used to evaluate the performance of each radiomics signature. The optimal radiomics label was selected to calculate the radiomics score (Rad-score), and constructed a radiomics (R) nomogram. According to the Rad-score threshold of the optimal radiomics signature, high-risk and low-risk groups for aMCI converting to AD were distinguished, and Kaplan-Meier survival curves were drawn to predict conversion to AD in aMCI patients. The clinical features affecting the progression of aMCI patients were determined by univariate logistic regression analysis, the nomogram of clinical features (C) was established, and finally the nomogram of radiomics & clinical features (R+C) was established. The efficacy of R nomogram, C nomogram, and R+C nomogram in predicting the progression of AD in aMCI patients at 3 years and 5 years was evaluated by C index. The decision curve was drawn to determine the application value of R nomogram, C nomogram and R+C nomogram in the clinical diagnosis. Results:The ROC curve showed that the right hippocampal radiomics signature had the best performance in predicting the conversion of aMCI to AD (the area under the curve was 0.989 for the training set and 0.897 for the validation set). Taking the Rad-score=21.374 of the right hippocampus radiomics label as the threshold, there were 70 cases in the high-risk group and 84 cases in the low-risk group in the training set, and 34 cases in the high-risk group and 32 cases in the low-risk group in the validation set. The mean time for conversion to AD in aMCI patients in the low-risk and high-risk groups predicted by the right hippocampal radiomics label in the training set was 42.5 and 25.0 months, and 41.3 and 22.4 months in the validation set, respectively. Both the nomogram and the decision curve indicated that the R+C nomogram showed greater benefit in predicting the conversion of aMCI to AD than the R nomogram and the C nomogram.Conclusions:The right hippocampal radiomics signature has good performance in predicting whether aMCI patients will progress to AD. The right hippocampal radiomics signature combined with the nomogram of clinical features can be used to predict the progression to AD in aMCI patients, which may help clinicians make decisions.
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Objective To explore denture re-repair method, the key steps and the results. Method The clinical data of the 72 cases with complete denture re-repair were retrospectively malyzed. Results The results of repair of 48 cases were effective( 15 cases with one of titanium palatal care), accounting for 67 percent, repair,23 cases were effective, accounting for 32%, Repair ineffective in 1 case, accounting for 1%. Repair effect of satisfaction with the extent of alveolar bone absorption was no significant relationship between the 72 cases in the mandibular alveolar ridge had the 58 cases of Lowland Technology, accounting for 80%. Conclusions In the process of making dentures,it is necessary to carefully deal with every step to obtain good denture retention. Improve denture retention for denture repair is essential. Repair material selection and a good physician-patient relationship is also a help to enhance effect.
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Of all 58 cases of knee osteoarthritis treated by acupuncture and moxibustion, 42 cases were recovered,(accounting for 72.5%), 14 cases were obviously improved (accounting for 24.1%), and 2 cases were ineffective (accounting for 3.4%). The total effective rate was 96.6%. This result demonstrated that acupuncture and moxibnstiou therapy has the good functions of dredging meridians and collaterals, activating qi and blood circulation, dispelling cold and dampness, and removing swollen to stop pain.
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0 05); the infection rate of deep wound Ⅲ degree was the lowest in delayed wound closing group. Conclusions It is key to improve the quality of the initial diagnosis and treatment,its measures are effective early stage debridement, the use of antibiotic, reasonable wound closing ,drainage,fixation, primary bone graft,bone plantation at phase Ⅰ and rigid selection of amputation; interlocking medullary nailing and external fixation stand with limited internal fixation are effective methods for the fixation of open fracture of tibia in the initial diagnosis and treatment.